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25 Deadliest U.S. Highways 2021

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Traffic accidents remain a leading cause of death in the United States, with many of our cities and suburbs built with cars, not public transportation, in mind. Due to high speed limits and the presence of vehicles of all sizes and types, highways are particularly dangerous. Data has shown that highways tend to be our nation’s deadliest roads.

So, what is America’s most dangerous highway? According to data from Teletrac Navman, Florida’s Interstate 4 (I-4) running from Tampa to Daytona Beach is the most dangerous. Between 2016 and 2019, 150 people died in traffic accidents on this stretch of road. Orlando saw the most fatalities during this time with 11 reported.

The full list of the 25 deadliest roads in the United States in 2021 are as follows (based on most deaths per mile):

  1. I-4: Tampa, Florida to Daytona Beach, Florida
    • Deaths per mile: 1.134
    • Length of Highway: 132 miles
    • Total Traffic Deaths (2016-2019): 150
    • Deadliest city: Orlando
  2. I-45: Galveston, Texas to Dallas, Texas
    • Deaths per mile: 0.913
    • Length of Highway: 285 miles
    • Total Traffic Deaths (2016-2019): 260
    • Deadliest city: Houston
  3. US 192: Four Corners, Florida to Indialantic, Florida
    • Deaths per mile: 0.867
    • Length of Highway: 75 miles
    • Total Traffic Deaths (2016-2019): 65
    • Deadliest city: Kissimmee
  4. I-17: Phoenix, Arizona to Flagstaff, Arizona
    • Deaths per mile: 0.707
    • Length of Highway: 146 miles
    • Total Traffic Deaths (2016-2019): 103
    • Deadliest city: Phoenix
  5. US 92: St. Petersburg, Florida to Daytona Beach, Florida
    • Deaths per mile: 0.706
    • Length of Highway: 177 miles
    • Total Traffic Deaths (2016-2019): 125
    • Deadliest city: Tampa
  6. I-12: Baton Rouge, Louisiana to Slidell, Louisiana
    • Deaths per mile: 0.666
    • Length of Highway: 86 miles
    • Total Traffic Deaths (2016-2019): 57
    • Deadliest city: Baton Rouge
  7. I-30: Aledo, Texas to North Little Rock, Arkansas
    • Deaths per mile: 0.646
    • Length of Highway: 367 miles
    • Total Traffic Deaths (2016-2019): 237
    • Deadliest city: Dallas, Texas
  8. I-95: Miami, Florida to Houlton, Maine
    • Deaths per mile: 0.637
    • Length of Highway: 1,908 miles
    • Total Traffic Deaths (2016-2019): 1,215
    • Deadliest city: Jacksonville, Florida
  9. I-19: Nogales, Arizona to Tucson, Arizona
    • Deaths per mile: 0.631
    • Length of Highway: 63 miles
    • Total Traffic Deaths (2016-2019): 40
    • Deadliest city: Sahuarita
  10. I-85: Montgomery, Alabama to Petersburg, Virginia
    • Deaths per mile: 0.613
    • Length of Highway: 666 miles
    • Total Traffic Deaths (2016-2019): 408
    • Deadliest city: Charlotte, North Carolina
  11. I-5: San Ysidro, California to Blaine, Washington
    • Deaths per mile: 0.609
    • Length of Highway: 1,381 miles
    • Total Traffic Deaths (2016-2019): 841
    • Deadliest city: Los Angeles, California
  12. 1-10: Santa Monica, California to Jacksonville, Florida
    • Deaths per mile: 0.597
    • Length of Highway: 2,460miles
    • Total Traffic Deaths (2016-2019): 1,469
    • Deadliest city: Houston and El Paso, Texas (tied)
  13. I-20: Scroggins Draw, Texas to Florence, South Carolina
    • Deaths per mile: 0.549
    • Length of Highway: 1,539 miles
    • Total Traffic Deaths (2016-2019): 845
    • Deadliest city: Dallas, Texas
  14. I-35W: Hillsboro, Texas to Denton, Texas
    • Deaths per mile: 0.528
    • Length of Highway: 85 miles
    • Total Traffic Deaths (2016-2019): 45
    • Deadliest city: Fort Worth
  15. I-24: Pulleys Mill, Illinois to East Ridge, Tennessee
    • Deaths per mile: 0.527 deaths per mile
    • Length of Highway: 317 miles
    • Total Traffic Deaths (2016-2019): 167
    • Deadliest city: Nashville, Tennessee
  16. I-75: Miami Lakes, Florida to Sault Ste. Marie, Michigan
    • Deaths per mile: 0.521
    • Length of Highway: 1,786 miles
    • Total Traffic Deaths (2016-2019): 930
    • Deadliest city: Atlanta, Georgia
  17. I-83: Baltimore, Maryland to Progress, Pennsylvania
    • Deaths per mile: 0.506
    • Length of Highway: 85 miles
    • Total Traffic Deaths (2016-2019): 43
    • Deadliest city: Baltimore
  18. I-26: Kingsport, Tennessee to Charleston, South Carolina
    • Deaths per mile: 0.496
    • Length of Highway: 305 miles
    • Total Traffic Deaths (2016-2019): 151
    • Deadliest city: North Charleston, South Carolina
  19. I-35E: Hillsboro, Texas to Denton, Texas
    • Deaths per mile: 0.496
    • Length of Highway: 97 miles
    • Total Traffic Deaths (2016-2019): 48
    • Deadliest city: Dallas
  20. US 199: Crescent City, California to Grants Pass, Oregon
    • Deaths per mile: 0.488
    • Length of Highway: 80 miles
    • Total Traffic Deaths (2016-2019): 39
    • Deadliest city: Grants Pass
  21. I-65: Mobile, Alabama to Gary, Indiana
    • Deaths per mile: 0.485
    • Length of Highway: 887 miles
    • Total Traffic Deaths (2016-2019): 430
    • Deadliest city: Nashville, Tennessee
  22. US 17: Punta Gorda, Florida to Winchester, Virginia
    • Deaths per mile: 0.462
    • Length of Highway: 1,189 miles
    • Total Traffic Deaths (2016-2019): 549
    • Deadliest city: Charleston, South Carolina
  23. US 11W: Knoxville, Tennessee to Bristol, Virginia
    • Deaths per mile: 0.45
    • Length of Highway: 111 miles
    • Total Traffic Deaths (2016-2019): 50
    • Deadliest city: Kingsport, Tennessee
  24. US 175: Dallas, Texas to Jacksonville, Florida
    • Deaths per mile: 0.447
    • Length of Highway: 114 miles
    • Total Traffic Deaths (2016-2019): 51
    • Deadliest city: Dallas
  25. I-66: Strasburg, Virginia to Arlington, Virginia
    • Deaths per mile: 0.446
    • Length of Highway: 76 miles
    • Total Traffic Deaths (2016-2019): 34
    • Deadliest city: Washington, D.C.

Teletrac Navman is the fleet management software provider behind these rankings, which are based on a four-year study and data from the Fatal Analysis Reporting System (FARS), courtesy of the National Highway Traffic Safety Administration (NHTSA).

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